“Artificial pancreas” shows promise in pregnancy

(Reuters) – Scientists have shown how an “artificial pancreas” can help pregnant women with type 1 diabetes and say their finding could significantly reduce cases of stillbirth and death among diabetic expectant mothers.

British researchers used a so-called “closed-loop insulin delivery system” or artificial pancreas, in 10 pregnant women with Type 1 diabetes and found it provided the right amount of insulin at the right time, maintained near normal blood sugar, and prevented dangerous drops in blood sugar levels at night.

“To discover an artificial pancreas can help maintain near-normal glucose levels in these women is very promising,” said Helen Murphy of Cambridge University, who led the study.

Mom’s blood carries fetus genome

A complete copy of the fetal genome exists in the mother’s blood, suggesting many prenatal diagnoses could be performed noninvasively

[Published 8th December 2010 07:00 PM GMT]

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Circulating in the blood of pregnant women is the full genome of their unborn child, according to a study published online today (December 8) in Science Translational Medicine.

Image: Wikimedia commons, Swangerschaft

The results suggest that whole genome sequencing of fetuses may be possible without invasive procedures, and hold implications for the prenatal diagnoses of every genetic disease.

This study provides “a window into the fetal genome,” said reproductive geneticist Diana W. Bianchi of the Mother Infant Research Institute at the Tufts University School of Medicine, who was not involved in the research. “In principle, that means that you could noninvasively prenatally diagnose anything because the sequence is going to be there.”

In 1997, chemical pathologist Dennis Lo of The Chinese University of Hong Kong and his colleagues discovered the presence of fetal DNA in maternal blood. Scientists have since developed noninvasive procedures to prenatally diagnose certain diseases. Down syndrome, for example, results from an abnormal number of chromosomes, and can be detected by searching mother’s blood for disproportionate amounts of DNA from different chromosomes. And genetic diseases inherited from the father may also be detected by searching the mother’s blood for the paternal mutation.

It was unclear, however, if the entire fetal genome was present in the maternal plasma, which would give clinicians more confidence in the tests currently available by limiting the rate of false-negative results. Additionally, it might make it possible to screen for genetic diseases that are caused by genetic mutations inherited from the mother, as well as sequence the entire genome of the unborn child, without subjecting the mother to invasive procedures that carry a small risk of miscarriage.